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KMID : 0379520230390040565
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한국독성학회지
2023 Volume.39 No. 4 p.565 ~ p.574
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Molecular mechanisms of 1,2-dichloroethane-induced neurotoxicity
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Yang Xiang
Xiaoshun Zhang
Zhiling Tian
Yibin Cheng
Ningguo Liu
Xiaojing Meng
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Abstract
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The production of industrial solvents and adhesives often utilizes 1,2-dichloroethane (1,2-DCE), a highly toxic halogenated hydrocarbon compound. Occupational 1,2-DCE poisoning occurs frequently and is a public health concern. Exposure to 1,2-DCE can damage the brain, liver, and kidneys. The main and most severe damage caused by exposure to 1,2-DCE is to the nervous system, especially the central nervous system. Current research on 1,2-DCE mainly focuses on the mechanism of brain edema. Several possible mechanisms of 1,2-DCE neurotoxicity have been proposed, including oxidative stress, calcium overload, blood?brain barrier damage, and neurotransmitter changes. This article reviews the research progress on 1,2-DCE neurotoxicity and the mechanism behind it to provide a scientific basis for the prevention and treatment of 1,2-DCE poisoning.
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KEYWORD
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1,2-dichloroethane · Neurotoxicity, Toxic brain edema, Occupational poisoning
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